98% Baicalein Powder CAS 491-67-8 | Botanical Extract Supplier
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Baicalein 98%
CAS No.: 491-67-8
Scientific Overview & Manufacturing Excellence
We specialize in the advanced botanical extraction and mass bulk supply of 98% Baicalein, a high-purity natural flavonoid monomer refined from premium dried scutellaria root (Scutellaria baicalensis). Through sophisticated multi-stage water extraction, macroporous resin separation, and low-temperature recrystallization purification technology, we produce uniform orange-yellow needle-like crystals.
The entire production workflow utilizes a pure physical purification process within our 100,000-class GMP dust-free closed workshops, ensuring full batch quality traceability. Every single batch is strictly calibrated via High-Performance Liquid Chromatography (HPLC) to guarantee a stable 98% monomer purity. We supply stable, low-impurity compliant raw materials for global cosmetic factories, health supplement brands, and biomedical research institutions.
Core Functions & Pharmacological Mechanisms
Powerful Antioxidant & Anti-aging
Baicalein efficiently clears excess free radicals inside the skin and cells. By reducing oxidative damage to tissues, it effectively delays cellular aging and fades dull complexions, offering superior antioxidant capacity compared to mixed botanical extracts.
Anti-inflammatory & Sensitive Soothing
As a targeted natural flavonoid, it suppresses the release of inflammatory mediators. It rapidly relieves facial redness, stinging, and sensitive discomfort caused by external stimulation, simultaneously helping to repair a fragile or compromised skin barrier.
Metabolic Regulation & Cardiovascular Protection
Applicable to oral health formulas, Baicalein optimizes human metabolic circulation and helps maintain vascular elasticity. It assists in stabilizing lipid levels and enhances the body's self-resistance to keep physical functions balanced and stable.
Target Application Scenarios & Formulation Objectives
Sensitive Soothing Skincare
Ideal for integrating into redness relief essences, barrier repair creams, anti-allergy toners, and intensive post-sun repair lotions.
Cardiovascular Health Supplements
Core active ingredient for lipid balance nutritional powders, oral anti-oxidation solid drinks, and daily metabolic conditioning herbal tablets.
Biomedical Laboratory Research
Deployed as a highly purified natural flavonoid standard reference substance and a reliable reagent for anti-inflammatory cell experiments.
Technical Specifications & Quality Standards
| Product Identity | Baicalein (Natural Flavonoid Monomer API) |
|---|---|
| Botanical Source | Premium Scutellaria Root (Scutellaria baicalensis) |
| Testing Method & Purity | HPLC Analysis; ≥ 98.0% Monomer |
| Physicochemical Properties | • Appearance: Orange-yellow Needle-like Crystals • Moisture: ≤ 5.0% • Ash Content: ≤ 4.0% • Mesh Size: 80-100 Mesh |
| Heavy Metals & Safety | Heavy Metal (Pb) ≤10ppm; Arsenic (As) ≤2ppm. Compliant with FDA/EU/GB safety standards. Low residual solvent. |
| Packaging Configurations | • Sample Scale: 1kg vacuum light-proof aluminum foil bag • Bulk Commercial: 25kg sealed light-blocking fiber drum *Private label and custom small batch specs available. |
| Storage & Shelf Life | Store sealed in a cool, dry & dark environment. Avoid high temperature & strong light. Validity is 24 months. |
Precautions & Formulation Guidelines
Light Sensitivity Storage: Baicalein crystal is highly sensitive to strong light. Long-term light exposure will cause discoloration and active degradation; it must be fully sealed and stored in a dark environment.
Solubility Matching: Slightly soluble in water, but easily soluble in ethanol, propylene glycol, and glycerin. Aqueous formulations require appropriate polyol cosolvents to prevent precipitation.
Production Operation Protection: Personnel must wear dust-proof masks and gloves during weighing and feeding to prevent respiratory and skin contact irritation from the fine crystal powder.
Formula pH Adaptation: The optimal formula pH range is 4.5–7.5. A strong alkaline environment will destroy the flavonoid structure and severely reduce its biological efficacy.
Compatibility Reminder: Avoid simultaneous matching with high-concentration oxidants in a formula, as this will prematurely consume the antioxidant activity of Baicalein.
Transportation Protection: Packaging must be strictly moisture-proof and light-proof. Prevent extrusion or impact damage that could lead to crystal leakage and compromised seal integrity.
Target Crowd Reference: Oral formulas intended for pregnant women and infants require thorough safety stability testing prior to mass commercial production.
Frequently Asked Questions (Procurement & Quality)
What is the difference between baicalein and scutellaria root total extract?
98% baicalein is a highly purified single flavonoid monomer tested by HPLC, boasting targeted anti-inflammatory and antioxidant efficacy. Scutellaria total extract is a mixed flavonoid blend with low single-ingredient content, typically utilized for mass-market, lower-cost health products.
Is baicalein easy to precipitate in water-based skincare?
It is slightly soluble in pure water. For water-based serum or toner formulations, adding 5%-10% propylene glycol or glycerin as a cosolvent can significantly improve its solubility and avoid crystallization or precipitation.
Why must baicalein be strictly stored away from light?
The Baicalein flavonoid molecular structure is photosensitive. Long-term exposure to ultraviolet and strong ambient light will lead to crystal darkening (discoloration) and a significant decline in its antioxidant and anti-inflammatory biological activity.
Can you supply complete registration documents for overseas cosmetics and health food?
Yes. With extensive global export experience supplying overseas beauty brands and health food factories, we provide a full set of HPLC chromatogram reports, COAs, MSDS, and heavy metal & microbial inspection certificates to fully support your brand filing and customs clearance.
Shaanxi Sunrise Pharmaceutical Co., Ltd.
Senior Independent Site Operations Specialist: Betty


