Dulaglutide (API & Research Grade)

Reliable Active Ingredient for Once-Weekly Peptide Preparation Research

RESEARCH COMPLIANCE:

This product is intended for Industrial Use or Scientific Research ONLY. It is a high-purity raw material and not a finished medication. Shaanxi Sunrise ensures full batch traceability and consistency under cGMP-aligned systems.

Product Overview

Shaanxi Sunrise Pharmaceutical is dedicated to providing ultra-high-purity Dulaglutide API, synthesized through advanced recombinant DNA technology and precise purification. Unlike smaller peptides, Dulaglutide is a GLP-1 analog fused to an IgG4 Fc fragment, which significantly extends its metabolic half-life.

Our API is optimized for high biological activity and batch-to-batch consistency, providing a solid foundation for pharmaceutical enterprises developing weekly injectable formulations.

Mechanism of Action (MOA)

Dual-Target Activation

As a GLP-1 receptor agonist, Dulaglutide mimics physiological incretin effects with enhanced stability:

GLP-1 Receptor Affinity: Specifically activates receptors to promote glucose-dependent insulin secretion.
Glucagon Inhibition: Effectively inhibits excessive glucagon release from the pancreas.
Gastric Regulation: Delays gastric emptying to stabilize post-meal glucose spikes.
IgG4 Fc Fusion: Large molecular structure avoids renal clearance and DPP-4 degradation, enabling a once-weekly dosing profile.

Applications & Pharmacological Scope

Our Dulaglutide API is specially designed for:

Weekly Preparation Development: Ideal for research into hypoglycemic drugs for injection with extended release profiles.
Type 2 Diabetes Research: Benchmark studies for glucose control and pancreatic β-cell protection.
Weight Management Research: Clinically proven mechanisms in regulating feeding behavior and satiety (raw material for research).

Frequently Asked Questions (FAQ)

What makes Dulaglutide different from Liraglutide?

Dulaglutide is a much larger fusion protein (approx. 60kDa) compared to Liraglutide (approx. 3.7kDa). Its large size prevents renal filtration, allowing for once-weekly dosing rather than once-daily.

Is the bioactivity of Shaanxi Sunrise Dulaglutide tested?

Yes. Every batch undergoes rigorous HPLC and cell-based assay testing to ensure that the GLP-1 receptor binding affinity and biological potency meet internal standards and cGMP requirements.

Can you provide customizable packaging?

We provide aseptic penicillin bottles in 1g and 5g standard sizes. Custom bulk packaging for industrial trials is available upon request to minimize material transfer loss.

How should the API be handled upon arrival?

Dulaglutide is a protein-based API. It must be stored at -20°C and protected from light. Avoid multiple freeze-thaw cycles once reconstituted to maintain structural integrity.