Melanotan II (MT II) Powder CAS No: 121062-08-6 Pharma Raw Material
Melanotan II (MT II) Powder CAS No: 121062-08-6 Pharma Raw Material
Melanotan II (MT II) Powder | CAS 121062-08-6 | Pharma Raw Material,CAS 121062-08-6, Pharma Raw Material,Melanotan II (MT II) Powder | CAS 121062-08-6
Product Name: Melanotan II
Product Purity :≥98.0%
CAS No:121062-08-6
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Description
Melanotan II (MT-2) Acetate
Ultra-High Purity Synthetic Cyclic Analog of α-MSH
Technical Specifications
| CAS Number | 121062-08-6 |
| Purity (HPLC) | ≥98.0% |
| Molecular Formula | C50H69N15O9 |
| Molecular Weight | 1024.18 Da |
| Peptide Content | ≥80.0% |
| Acetate Content | ≤12.0% |
| Bacterial Endotoxins | ≤50 EU/mg |
| Appearance | Lyophilized White Powder |
| Storage Conditions | -20℃, Sealed, Light-protected |
Product Introduction
Shaanxi Sunrise Pharmaceutical (Shaanxi Sunrise Pharmaceutical Co., Ltd.) provides high-purity Melanotan II (MT-2), a synthetic cyclic analog of α-melanocyte-stimulating hormone. Through precise chemical modifications—including N-terminal acetylation, C-terminal amidation, and cyclic structure at positions 4 and 10—this peptide offers enhanced biological stability and receptor affinity, serving as a critical tool for melanocortin receptor (MCR) research.
Pharmacological Actions
Pigment Regulation
Stimulates MC₁R to activate tyrosinase, accelerating endogenous melanin synthesis and melanosome transport.
Metabolic Control
Acts on hypothalamic MC₄R to suppress appetite and modulate glucose-lipid metabolic balance.
Neuro-Efficacy
Activates MC₃R/MC₄R to inhibit pro-inflammatory cytokines (TNF-α, IL-6) and promote neurotrophic factors.
Scientific Mechanism of Action
Receptor Binding: Its stable cyclic structure ensures high affinity for G-protein coupled MCRs, initiating intracellular signaling cascades.
Signal Amplification: Triggers the Adenylate Cyclase (AC) pathway, increasing cAMP levels and activating Protein Kinase A (PKA).
Gene Transcription: PKA phosphorylates MITF, which regulates the transcription of essential enzymes like Tyrosinase and TRP-1 in the nucleus.
Downstream Modulation: Regulates metabolic and inflammatory responses through the PLC-IP₃-DAG pathways and AKT inhibition.
Primary Research Applications
Pigmentary Disorders: Research on Vitiligo and Albinism management via pigment repair pathways.
Anti-Obesity Drug Screening: Target validation for MC₄R-selective compounds and appetite suppression mechanisms.
Neuroscience: Investigation of neuroprotective effects in ischemic brain injury and neuroinflammation models.
Photobiology: Studies on skin natural defense mechanisms against UV radiation and oxidative stress.
USAGE DECLARATION & COMPLIANCE:
This product is intended strictly for industrial use or scientific research purposes. It is not for human clinical trials, diagnosis, or medical treatment. Shaanxi Sunrise Pharma complies with ICH Q7 guidelines. Customers must provide legitimate institutional credentials for order processing.