Desmopressin acetate ≥ 95% CAS No: 16789-98-3
Desmopressin acetate ≥ 95% CAS No: 16789-98-3
Desmopressin acetate ≥ 95% CAS No: 16789-98-3,Desmopressin acetate ≥ 95% ,CAS No: 16789-98-3,Desmopressin acetate CAS No: 16789-98-3
Product Name: Desmopressin Acetate API Powder
product purity: ≥ 95%
CAS No: 16789-98-3
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Description
Research Grade ≥95%
Desmopressin Acetate
Selective Vasopressin V2 Receptor Agonist | High-Purity Synthetic Analogue
Product Description
Desmopressin Acetate is a synthetic structural analogue of the natural hormone arginine vasopressin (AVP). Through strategic molecular modifications—specifically the deamination of 1-cysteine and the substitution of 8-L-arginine with 8-D-arginine—it exhibits significantly enhanced antidiuretic potency and prolonged metabolic stability.
Superior V2 Receptor Selectivity
Unlike natural vasopressin, which acts non-selectively on both V1 and V2 receptors, our Desmopressin Acetate is engineered for extreme V2-selectivity. This allows researchers to isolate antidiuretic and endothelial responses without the interference of V1-mediated vasoconstriction.
| Compound | V1 Activity (Vasopressor) | V2 Activity (Antidiuretic) | Selectivity Ratio (V2:V1) |
|---|---|---|---|
| Natural AVP | 1.0 | 1.0 | 1 : 1 |
| Desmopressin (Sunrise) | < 0.01 | > 3.0 | ≈ 3000 : 1 |
Scientific Insight: The D-Arginine substitution at the 8th position is the key structural driver for this profound selectivity, effectively decoupling the renal effects from the vasopressor response in experimental models.
Core Research Applications
Renal Physiology
Studying AQP2 trafficking and water reabsorption mechanisms in the collecting ducts.
Hematology Models
Investigating the release of vWF and Coagulation Factor VIII from endothelial cells.
GPCR Signaling
Researching V2-receptor specific ligand-receptor kinetics and second messenger (cAMP) pathways.
Peptide Stability
Evaluating enzyme resistance and oral/nasal bioavailability in drug delivery research.
B2B Procurement FAQ
Q1: Can I request HPLC and Mass Spec raw data?A: Yes. For every batch, Shaanxi Sunrise provides a comprehensive COA. Raw HPLC and MS data are available to institutional clients upon request for validation.
Q2: What is the recommended long-term storage?A: The product is most stable when stored at 2-8°C, shielded from light. Strictly avoid repeated freeze-thaw cycles after reconstitution.
Q3: Do you support university/institutional R&D orders?A: We specialize in supplying high-purity reagents to pharmaceutical R&D labs, biotech firms, and academic institutions worldwide.