Desloratadine Powder ≥98% CAS No: 100643-71-8
Desloratadine Powder ≥98% CAS No: 100643-71-8
Desloratadine Powder ≥98% CAS No: 100643-71-8,CAS No: 100643-71-8,Desloratadine Powder ≥98% ,Desloratadine
Product Name: Desloratadine Powder
Product Purity: ≥98%
CAS No.: 100643-71-8
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Description
Desloratadine (High-Purity Micronized Powder)
Gold Standard Antihistamine | Active Metabolite | CAS 100643-71-8
Technical Storage: Photosensitive material. Maintain seal in light-resistant containers. Stable for 24 months under recommended cool, dry conditions.
Product Overview
Desloratadine is a third-generation, long-acting tricyclic antihistamine that functions as a selective peripheral histamine H₁-receptor antagonist. As the principal active metabolite of loratadine, it possesses superior receptor affinity without the need for hepatic transformation. Shaanxi Sunrise Pharmaceutical offers premium micronized powder optimized for various pharmaceutical dosage forms and high-end biochemical research.
| CAS Registry No. | 100643-71-8 |
| Chemical Formula | C₁₉H₁₉ClN₂ |
| Molecular Weight | 310.85 g/mol |
| Physical State | White crystalline powder |
| Solubility | Soluble in Ethanol/DMSO; Poor in Water |
| Grade | Research & Industrial Grade |
| Standard Pack | 1kg/Bag; 25kg/Drum |
Pharmacological Key Advantages
Enhanced Potency
Direct active metabolite mechanism ensures faster symptom relief compared to pro-drug alternatives like Loratadine.
CNS Safety Profile
Negligible penetration of the blood-brain barrier ensures zero sedation, making it suitable for daytime administration.
Cytokine Inhibition
Demonstrates additional anti-inflammatory properties by inhibiting the release of pro-inflammatory mediators from mast cells.
Detailed Mechanism of Action
Desloratadine provides multi-pathway relief from allergic responses through its high-affinity binding:
Selective H₁ Antagonism: It prevents histamine from binding to H₁ receptors in peripheral tissues, thereby curbing vasodilation and tissue edema.
Inverse Agonism: Stabilizes the H₁ receptor in its inactive conformation, proactively reducing baseline allergic signaling.
Long Half-Life: A sustained 27-hour half-life supports a simplified once-daily dosing regimen for chronic urticaria and allergic rhinitis.
Technical Support FAQ
Why choose Desloratadine over Loratadine?
Desloratadine is the active form. It does not rely on the liver's CYP450 enzyme system to be activated, which reduces the risk of drug-drug interactions and provides more predictable therapeutic outcomes.
What are the solubility parameters for lab formulation?
Desloratadine is lipophilic. For analytical preparations, it is highly soluble in DMSO (≥31 mg/mL) and Ethanol. In aqueous buffers, solubility is extremely low, so co-solvents or surfactants may be required for liquid studies.
How does Shaanxi Sunrise ensure quality compliance?
We provide a comprehensive Certificate of Analysis (COA) with every shipment. Our QC protocols include HPLC for purity, NMR for structural verification, and rigorous testing for residual solvents and heavy metals.