High-Performance DOTA Chelator

Gold Standard Macrocyclic Ligand | CAS 60239-18-1 | Shaanxi Sunrise Pharmaceutical

High Purity ≥99% (HPLC)

Metal-Free Synthesis Process

Low Residual Solvents (ICH)

Multi-Batch Consistency Verified

DOTA (1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid) White Powder

Handling Note: DOTA is sensitive to moisture (hygroscopic). For long-term shelf life, store at 2-8°C in a desiccated environment. Batch-specific chromatograms are included with every delivery.

Professional Product Introduction

DOTA (1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid) is a cornerstone macrocyclic polyamine carboxylic acid chelating agent. At Shaanxi Sunrise Pharmaceutical, we utilize advanced synthesis pathways to ensure DOTA with ultra-low trace metal interference. This makes it the ideal ligand for forming high-stability complexes with lanthanides and radiometals (Gd³⁺, ⁶⁸Ga, ¹⁷⁷Lu, ⁹⁰Y), supporting the most demanding applications in nuclear medicine and molecular imaging.

CAS Number	60239-18-1
Chemical Formula	C₁₆H₂₈N₄O₈
Molecular Weight	404.41 g/mol
Appearance	White to off-white crystalline powder
HPLC Purity	≥ 99.0% (Certified)
Heavy Metals	≤ 10 ppm
Packaging	1g, 5g, 10g, 100g or bulk custom

Core Technical Advantages

Unrivaled Kinetic Stability

The "rigid cage" effect of the 12-membered ring provides superior thermodynamic stability compared to open-chain chelators (like DTPA), ensuring zero isotope leakage in physiological conditions.

Optimized Labeling Yields

Our ultra-pure grade DOTA maximizes radio-labeling efficiency, reducing the need for extensive post-labeling purification in PET/SPECT tracer production.

Bifunctional Versatility

The four acetic acid arms offer multiple coordination sites or can be activated (e.g., as NHS esters) for conjugation to peptides, antibodies, or nanoparticles.

Pharmacology & Mechanism

The performance of DOTA-based agents relies on the precise coordination of metal ions within its macrocyclic cavity:

The Coordination "Cage": DOTA acts as an octadentate ligand. The four nitrogen atoms in the ring and four carbonyl oxygens from the acetate groups form a highly stable, square-antiprismatic coordination geometry.
Radionuclide Transport: By forming an inert complex, DOTA prevents the toxic buildup of free metal ions (like Gadolinium or Lutetium) in the liver or bone, ensuring safe excretion via the kidneys.
Molecular Precision: In Theranostics, DOTA serves as the bridge, linking the diagnostic isotope (imaging) and the therapeutic isotope (treatment) to the same targeting biomolecule.

Technical Support & FAQ

What is the best way to prepare a DOTA stock solution?

DOTA has low solubility in pure water at acidic pH. We recommend suspending DOTA in deionized water and gradually adding 0.1M NaOH or ammonium acetate buffer until the pH reaches 6.0-7.0, at which point the DOTA will dissolve completely as a salt.

Is your DOTA suitable for Gadolinium (Gd) contrast agent research?

Yes. Our DOTA is specifically tested for lanthanide coordination. The high purity ensures that the resulting Gd-DOTA complex remains stable without free Gd³⁺ ions, which is critical for toxicity studies.

How do you ensure batch-to-batch consistency?

Shaanxi Sunrise follows strict GMP-aligned quality control. Every batch undergoes ¹H-NMR, LC-MS, and HPLC testing. We also monitor residual moisture and trace metal content to ensure your research results are reproducible.

What are the lead times for bulk orders (kg+)?

We maintain a regular stock for research-grade quantities (up to 500g). For bulk commercial orders, the typical lead time is 2-3 weeks depending on the specific packaging requirements.